Research
The Lin lab uses genetic, genomic, and in vitro approaches to study the development and regeneration of the nervous system. We use the mouse olfactory system as a model because of the many molecular genetic tools available, and because the olfactory system regenerates throughout the life of the animal. We focus on identifying genes that regulate these processes, and how this regulation may differ during regeneration.
Genetic, genomic, and in vitro approaches towards axon guidance during development and regeneration in the mouse olfactory system
Visualization of primary neuronal cultures with DAPI and RFP immunostaining
Neurons expressing guidance cues fused to GFP
Multiphoton microscopy of neurons in vivo
Cultured neurons growing on a surface patterned with guidance cues
Abstract cell image
Members
Meet our lab members!
David Lin, PhD
Principal InvestigatorBS Harvard University, PhD UC Berkeley
Adam Bisogni, PhD
Post DocBS & PhD Cornell University
Longsha Liu
UndergraduateAlexander Chung
UndergraduateAnirudh Chitale
UndergraduateIshmat Hoque
UndergraduateAndrew Martinez
UndergraduateJoe Hayes
UndergraduateSelect Publications
1. Ghazanfar, S., Bisogni, A.J., Ormerod, J.T., Lin, D.M. and Yang, J.Y.H. Integrated single cell data analysis reveals cell specific networks and novel coactivation markers. BMC Systems Biology, (2016) 10 (suppl5): 127 2. Dewey, C.W., Estey, C., Rishniw, M., Lin, D.M., Sackman, J., Bouma, J., Burkland, E. A subset of dogs with presumptive idiopathic epilepsy show hippocampal asymmetry: a volumetric comparison with non-epileptic dogs using MRI. Frontiers in Veterinary Science, (2017),4:183. 3. Esteve, A., Dollat, X., Lin, L., Lin, D., Cerf, A. Easy alignment strategy for multi-level micropatterning. Microelectronic Engineering (2018), v193, 7-12. 4. Bisogni, A.J., Ghazanfar, S., Williams, E.O., Marsh, H., Yang, Y.H., and Lin, D.M. Tuning of delta protocadherin adhesion through combinatorial diversity. eLife (2018) 7 e41050. 5. Lin, Y., Ghazanfar, S., Strbenac, D., Wang, A., Patrick, E., Lin, D.M., Speed, T., Yang, JYH, Yang, P. Evaluating stably expressed genes in single cells. Gigascience, (2019), 8(9): giz106. Browse PubMed for a complete listing of Dr. Lin's publications
Join us
For postdoctoral, graduate, or undergraduate opportunities, please email Dave Lin
Our lab is currently recruiting post-doctorate candidates and undergraduate researchers.
Department of Biomedical Sciences Cornell University College of Veterinary Medicine T2 006A Veterinary Research Tower, Box 16 Ithaca, NY 14853-6401 Office: 607-253-4360 Email: dml45@cornell.edu
